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Neuroblastoma and the unmet need

Neuroblastoma and the unmet need

Neuroblastoma is the most common extra-cranial solid tumour in children and is a leading cause of cancer-related death in children1

  • Neuroblastomas are derived from neural crest cells within the sympathetic nervous system, and can be found intra-abdominally, very often in the adrenal glands1
  • Neuroblastomas can, however, be located anywhere along the sympathetic nervous system, including the neck, chest, or pelvis1
  • Patients can often present with a broad range of symptoms, including:2
  • Weight loss
  • Enlarging mass
  • Pain
  • Eye bulging/bruising
  • Swelling in neck and face
  • Fever

Intensive research has led to improvements in high-risk neuroblastoma
survival, but a high unmet need remains3

Probability of overall survival (OS) among 3,352 Children’s Oncology Group (COG) patients with high-risk neuroblastoma diagnosed between 1990 and 2010 according to era. Five-year OS rate (+ SE) for patients diagnosed between 1990 and 1994 (n=497) 2000 to 2004 (n=1,015) and 2005 to 2010 (n=1,484) are 29% + 0.02, 47% + 0.02, and 50% + 0.02, respectively.3

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GL-DNB-2200033 | February 2023

References

  1. Moreno L et al. British Medical Bulletin 2013; 108: 173–188.
  2. American Cancer Society. Signs and Symptoms of Neuroblastoma. Available at: https://www.cancer.org/cancer/neuroblastoma/detection-diagnosis-staging/signs-and-symptoms.html. Accessed February 2023.
  3. Pinto NR et al. J Clin Oncol 2015; 33: 3008–3017.

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